Is self-organization the answer to the foundational question of why life exhibits such complexity? And can it also serve as a guiding framework for how best to save complex webs of biodiversity amid the onslaughts of the modern world? Self-organization exists throughout nature and socioeconomic structures. It refers to the spontaneous emergence of collective, complex order within a disordered system, due to localized interactions that follow simple rules, and occurring without external controls. While conceptually abstract, given that uncertainty lies at its core, the applications of self-organization are everywhere. Advancing our understanding of the non-linear processes within complex systems that drive self-organization is also becoming increasingly important for developing evidence-based policies in a world defined by interdependence and escalating stressors. Indigenous cultures, such as those that live within complex socio-ecological systems in the Amazon ecoregion, have long embraced these principles of uncertainty, interconnectedness, and non-linear dynamics. How will their wisdom, experience, and models of socio-ecological systems integrate with evidence-based policies for protecting the Amazon ecoregion? Safeguarding the Amazon is one of our world’s most pressing, complex, and vital global challenges. Among the strategies gaining traction, supported by increasing financial investment, is the intriguing proposition to transform a portion of the region’s immense biodiversity into a sustainable “bioeconomy.” However, these proposals, and the policy makers responsible for negotiating their implementation across boundaries and cultures, often lack an understanding of how both economies and ecologies self-organize and scale. Data-driven models of self-organization and critical collective phenomena in the natural world and within traditional Indigenous sociocultural structures, along with adaptive context-based frameworks, can help guide the transboundary development of a decentralized and circular socio-bioeconomy for the Amazon. Self-Organized Criticality and the Edge of Chaos Pioneering research on self-organized criticality (SOC) began in the 1980s and was made accessible to a wider audience by...