Over the past two decades, complexity science has matured from its origins as a small, largely esoteric subfield of theoretical statistical physics and mathematics into an expansive area of inquiry that bridges disciplines and addresses some of the world’s most acute interconnected challenges.  Nowhere has this interdisciplinary, applied process become more apparent than with the ongoing convergence of complexity and health.  This convergence is happening at all scales—individual and collective, private and public—across approaches to prevention, treatment, management, and containment in integrative and public health spaces, as well as through applied research and innovation. “Our methodological approach goes on and on down to the level of microbiology and finally finding cures for many diseases,” says Italian American physicist and complex networks scientist Alessandro Vespignani. “All that goes through networks and through a vision that has complex systems at the core. Network science is a way to approach complex systems,” Vespignani explained from within Northeastern University’s Network Science Institute, where he serves as director, leads the Laboratory for the Modeling of Biological and Socio-technical Systems (MOBS) lab, and heads several impactful public health initiatives. “We look at elements and their interactions, and we do not get rid of nonlinear phenomena, feedback loops, et cetera, that exist in real world systems; we need to consider those,” Vespignani continues. “And in that sense, there is even more urgency in the work that we as a community do to respond to those challenges and to be of service to the society.” Explore the full InterDialogue with Alessandro Vespignani. The COVID-19 pandemic served as a critical moment of applied research and broad engagement with public health policy for those, like Vespignani, who work at the interface of complexity and health. But theoretical research and its translation into experiments and action began several years prior and...

Why life is complex and — most importantly — what is the origin of the over abundance of complexity in nature? This is a fundamental scientific question which, paraphrasing the late Per Bak, “is screaming to be answered but seldom is even being asked.” In this three-article series, we review recent attempts across several scales to understand the origins of complex biological problems from the perspective of critical phenomena. Following a broad introduction to complexity, criticality and universality in Part 1, to illustrate the approach, three cases will be discussed in Parts 2 and 3; large scale brain dynamics, the characterization of spontaneous fluctuations of proteins, and the physiological complexity of the cell mitochondria network. Introduction In the last decade, we have witnessed an escalating interest in complex biological phenomena at all levels including macroevolution, neuroscience at different scales, and molecular biology. Potential progress is of paramount importance, thus we shall examine a bit how we are currently proceeding to carve out these new areas, starting with asking whether biological phenomena are more or less complex than other fundamental problems in physics. The answer is not clear at first, however striking differences exist in the approaches as well as in the sociology of both fields.  The history of physics records many important efforts in search for universality; large classes of phenomena must be explained in terms of a few fundamental laws. In contrast, biology more often seems to emphasize unique and singular aspects; because not all organisms are alike, there is a large diversity of species, families, etc… such that taxonomy ends up prevailing over integration of knowledge. This apparent uniqueness of each biological phenomena in some cases leads to overspecialization, which may, from time to time, encourage the creation of a sub-discipline for each new group of complex biological...

Over the short span of just 300 years, since the invention of modern physics, we have gained a deeper understanding of how our universe works on both small and large scales. Yet, physics is still very young and when it comes to using it to explain life, physicists struggle. Even today, we can’t really explain what the difference is between a living lump of matter and a dead one. But my colleagues and I are creating a new physics of life that might soon provide answers. More than 150 years ago, Darwin poignantly noted the dichotomy between what we understand in physics and what we observe in life – noting at the end of The Origin of Species “…whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been and are being evolved”. The importance of time Isaac Newton described a universe where the laws never change, and time is an immutable and absolute backdrop against which everything moves. Darwin, however, observed a universe where endless forms are generated, each changing features of what came before, suggesting that time should not only have a direction, but that it in some ways folds back on itself. New evolutionary forms can only arise via selection on the past. Presumably these two areas of science are describing the same universe, but how can two such diametrically opposite views be unified? The key to understanding why life is not explainable in current physics may be to reconsider our notions of time as the key difference between the universe as described by Newton and that of Darwin. Time has, in fact, been reinvented many times through the history of physics. Although Newton’s time was fixed and absolute, Einstein’s time became a dimension...

Our Elemental Origins It is easy for us humans – with our self-proclaimed superior intelligence over other species, and ability to innovate and exploit the natural world to our whims – to forget or ignore that we are in fact part of nature. This is not solely an existential statement, or even an acknowledgement of the dependency that we have on nature for our long-term survival as a species. From our behaviors and physiology, to the very molecules, elements and atoms that makeup the cells of our body, we are nature. One must even expand the meaning of “the natural world” to truly appreciate where we come from. The history of those aforementioned atoms and elements in particular, extends well beyond the evolution of our species, and even beyond the evolution of our planet and solar system. The fundamental building blocks that makeup our bodies and the diverse and beautiful planet that we depend upon, are born from the cosmos. To illustrate this interconnectedness between our existence and health, the natural world here on earth, and the vast universe, let us focus in this article on one specific element: magnesium. But before we do so, let’s give a shout-out to carbon, lithium, iron, gold and so many other elements whose multi-billion year biographies can also uniquely illustrate the connection between our present reality as resource consuming earthlings and the high-energy events that have happened during the evolution of the universe. Magnesium Magnesium is a metal with the atomic number 12, and is believed to be the 9th most prevalent element in the universe. Magnesium is the 8th most abundant element found in the earth’s crust, which is made up of approximately two percent magnesium through a range of compounds (it does not occur on its own naturally on earth). Magnesium is also the third most dissolved...