Why life is complex and — most importantly — what is the origin of the over abundance of complexity in nature? This is a fundamental scientific question which, paraphrasing the late Per Bak, “is screaming to be answered but seldom is even being asked.” In this three-article series, we review recent attempts across several scales to understand the origins of complex biological problems from the perspective of critical phenomena. Following a broad introduction to complexity, criticality and universality in Part 1, to illustrate the approach, three cases will be discussed in Parts 2 and 3; large scale brain dynamics, the characterization of spontaneous fluctuations of proteins, and the physiological complexity of the cell mitochondria network. Introduction In the last decade, we have witnessed an escalating interest in complex biological phenomena at all levels including macroevolution, neuroscience at different scales, and molecular biology. Potential progress is of paramount importance, thus we shall examine a bit how we are currently proceeding to carve out these new areas, starting with asking whether biological phenomena are more or less complex than other fundamental problems in physics. The answer is not clear at first, however striking differences exist in the approaches as well as in the sociology of both fields. The history of physics records many important efforts in search for universality; large classes of phenomena must be explained in terms of a few fundamental laws. In contrast, biology more often seems to emphasize unique and singular aspects; because not all organisms are alike, there is a large diversity of species, families, etc… such that taxonomy ends up prevailing over integration of knowledge. This apparent uniqueness of each biological phenomena in some cases leads to overspecialization, which may, from time to time, encourage the creation of a sub-discipline for each new group of complex biological...